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Abstract #3368

Toxicological Effect of Thallium in Mice by NMR-Based Metabolic Profiling of Urine

Ritu Tyagi1, Poonam Rana1, Ahmad Raza Khan1, M Memita Devi1, Shubhra Chaturvedi2, Subash Khushu1

1NMR Research Centre, INMAS, Delhi, India; 2Division and Cyclotron & Radiopharmaceutical Sciences, INMAS, Delhi, India

Thallium is a heavy metal that gets accumulated in liver and kidney after absorption and causes renal and hepatotoxicity. NMR spectroscopy based study has been conducted for identification of metabolite markers for thallium toxicity. Urine samples were collected from mice at 3, 24 and 96 hrs post injection of low and high dose of Tl2SO4. Spectral analysis showed dose dependent alterations in various metabolites involved in renal and hepatic toxicity and could be seen as early as 3 hrs post injection and may be further helpful in devising the protocol for decorporation of such harmful elements.