Meeting Banner
Abstract #4568

Aged Vs. Fresh Blood for the Treatment of Hemorrhagic Shock; Differential Effect on Liver Outcome and Possible Mechanism

Idit Matot1, Miriam Katz2, Orit Pappo3, Nathalie Corchia4, Gregory Barshtein5, Shaul Yedgar5, Rinat Abramovitch, 6

1Department of Anesthesiology & Intensive Care, Tel Aviv, Sourasky Medical Center, Tel Aviv, Israel; 2Department of Anesthesiology, Rabin Medical Center, Petach Tiqva, Israel; 3Pathology, Hadassah Hebrew University Medical Center, Jerusalem, Israel; 4he Goldyne Savad Institute of Gene Therapy, Hadassah Hebrew University Medical Center, Jerusalem, Israel; 5Department of Biochemistry, Hebrew University, Jerusalem, Israel; 6MRI/MRS lab HBRC, Hadassah Hebrew University Medical Center, Jerusalem, Israel

Concerns have recently been raised about the safety of transfusing stored-blood. Several studies have suggested that the risk of complications increases when transfused blood has been stored for long period. The liver is a target for injury in low flow states associated with trauma and hemorrhage. We studied the effect of blood resuscitation (fresh vs. Stored-blood) on liver injury. In rats, transfusion of blood stored longer than 4 days increased liver injury. This was associated with significant changes in the viscoelastic characteristics of the stored-blood and unrelated to the oxygen-carrying-capacity, cytokines in the stored-blood or the RBC/endothelial cells adherence properties.