Comparative Stability of Nonionic Linear and Ionic Macrocyclic Gadolinium Chelates in Renally-Impaired Rats

Jean-Marc Ide¹, Nathalie Fretellier¹, Anne Dencausse¹, Nicolas Poveda¹, Galle Jestin¹, Claire Hollenbeck¹, Marc Port¹, Jean-Sbastien Raynaud¹, Philippe Robert¹, Claire Corot¹

In rats with subtotal nephrectomy receiving single injections (2.5 mmol/kg) of gadodiamide (Omniscan) for 5 consecutive days, 62 +15% of the total plasma gadolinium concentration measured at sacrifice was found to be free while the free Gd3+ concentration in plasma was < limit of detection for gadoterate (Dotarem). Relaxometry study of the skin and the bone indicate gradual in vivo dechelation and release of free Gd3+ in rats receiving the linear GC gadodiamide (increase in the r1 relaxivity constant over time in the skin and higher r1 value vs. ex vivo matrix in skin and bone), while gadoterate remained stable.