Hyperphosphataemia Reveals Skin Lesions in Gadodiamide-Treated Rats with Low Renal Function

Jean-Marc Ide¹, Nathalie Fretellier¹, Sylviane Guerret², Marie-Christine De Goltstein¹, Anne Dencausse¹, Nicolas Poveda¹, Claire Hollenbeck¹, Walter Gonzalez¹, Ccile Factor¹, Claire Corot¹

Rats with subtotal nephrectomy received a normal or high-phosphate diet and were allocated to single injections of 2.5 mmol/kg of gadodiamide (Omniscan) or saline for 5 consecutive days. Hyperphosphataemia enhanced histological lesions (increase in dermal cellularity, abnormalities in dermal collagen fibres and TGF-beta-1 immunostaining) and revealed macroscopic skin lesions. In the gadodiamide + high phosphate diet group, the total plasma gadolinium concentration was higher in the rats with skin lesions than in the rats without lesions as well as the free Gd3+ concentration.