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Abstract #4695

Hyperphosphataemia Reveals Skin Lesions in Gadodiamide-Treated Rats with Low Renal Function

Jean-Marc Ide1, Nathalie Fretellier1, Sylviane Guerret2, Marie-Christine De Goltstein1, Anne Dencausse1, Nicolas Poveda1, Claire Hollenbeck1, Walter Gonzalez1, Ccile Factor1, Claire Corot1

1Research, Guerbet, Roissy-Charles de Gaulle cedex, France; 2Novotec, Lyon, France

Rats with subtotal nephrectomy received a normal or high-phosphate diet and were allocated to single injections of 2.5 mmol/kg of gadodiamide (Omniscan) or saline for 5 consecutive days. Hyperphosphataemia enhanced histological lesions (increase in dermal cellularity, abnormalities in dermal collagen fibres and TGF-beta-1 immunostaining) and revealed macroscopic skin lesions. In the gadodiamide + high phosphate diet group, the total plasma gadolinium concentration was higher in the rats with skin lesions than in the rats without lesions as well as the free Gd3+ concentration.