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Abstract #4722

DTI at Different B-Values in Kidneys in Children with Unilateral Pylonephritis

Claudia Testa1, Laura Miglio2, David Neil Manners1, Caterina Tonon1, Emil Malucelli1, Bruno Barbiroli1, Andrea Pasini2, Giovanni Tani2, Raffaele Lodi1

1MR Spectroscopy Unit, Department of Internal Medicine, Aging and Nephrology, University of Bologna, Bologna, Bo, Italy; 2Paediatric Radiology Unit, Department of Woman, Child and Adolescent Health, University of Bologna, Bologna, Italy

DTI was used to evaluate renal damage in patients with chronic pyelonephritis. In 12 children affected by unilateral pyelonephritis as assessed by renal scintigraphy (Tc99-DMSA), axial DT images were acquired at b-values of 0, 100, 300, 600, 800 s/mm2. The mean diffusivity (D) and fractional anisotropy (FA) maps were generated for each b-value. We found that FA discriminated values from cortex and medulla better than D in healthy kidneys. D and FA decreased in affected kidneys at each b-values, in particular in the cortex of kidney poles. Changes of D and FA correlated with the degree of functionality damage found by scintigraphy.