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Abstract #5138

A Comparison of Three CEST Imaging Methods

Zhongliang Zu1, Ke Li1, Daniel Frank Gochberg1

1Radiology, Vanderbilt University, Nashville, TN, United States

Three CEST imaging methods including continuous-wave, pulsed-, and spoiled gradient recalled CEST are numerically optimized and compared using simulations and a creatine/agarose tissue phantom. We found that the average irradiation power is a more meaningful sequence metric than is the average irradiation field; We also found that the SPGR-CEST provides an alternative to the EPI based CW- and pulsed-CEST imaging methods that avoids the artifacts inherent to multi-echo acquisitions, though at the cost of lower CNR.