Shing-Ru Chen1, Yi-Ru Lin2, Posse Stefan3,4, Shang-Yueh Tsai5
1Graduate Institute of Biomedical Engineering, National Taiwan University of Science & Technology, Taipei, Taiwan; 2Department of Electronic Engineering, National Taiwan University of Science & Technology, Taipei, Taiwan; 3Department of Neurology, School of Medicine, University of New Mexico, Albuquerque, NM, United States; 4Department of Electrical & Computer Engineering, University of New Mexico, Albuquerque, NM, United States; 5Department of Electrical Engineering, Chang Gung University, Taoyuan, Taiwan
Fatty liver as a common disease in modern life can be associated with a variety of disorders. Quantification of liver fat content relies on liver biopsy. Recently it has been shown that MRS can be used as an alternative method to measure liver fat. In this preliminary report, proton echo-planar spectroscopic imaging (PEPSI) is proposed to quantify spatial distribution of fat content in liver. Feasibility and reproducibility of liver MRSI were investigated. Results showed that PEPSI is able to detect liver fat content within short acquisition time. And the measured lipid fat fraction is highly reproducible.