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Abstract #1037

Distinction of Invasive Lobular Carcinoma, Invasive Ductal Carcinoma & Healthy Breast Tissue In Vivo with L-COSY at 3T

Saadallah Ramadan1, Hayden Nicholas Box1, Pascal Baltzer2, Alexander Lin1, Peter Stanwell3,4, Eva Gombos1, Werner a Kaiser2, Carolyn Mountford1

1Radiology, Brigham & Women's Hospital, Boston, MA, United States; 2Radiology, Institute of Diagnostic & Interventional Radiology, Jena, Germany; 3School of Health Sciences, The University of Newcastle, Newcastle, NSW, Australia; 4Radiology, Brigham & Womens Hospital, Boston, MA, United States

This pilot study investigates changes to lipid chemistry in the breast that occur with invasive cancer, using Localized COrrelated SpectroscopY (L-COSY). Early results indicate that the COSY method distinguishes lobular from ductal carcinoma and from healthy breast tissue based on the chemical shift of the resonance in the 3.00-3.30ppm region and the ratio of lipid peak volumes .