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Abstract #2438

Measuring Cortical Thickness in Brain MRI Volumes to Detect Focal Cortical Dysplasia

Ljiljana Platisa1, Anthony De Smet1, Ivana Despotovic1, Asli Kumcu1, Karel Deblaere2, Aleksandra Pizurica1, Ewout Vansteenkiste1, Wilfried Philips1

1TELIN-IPI-IBBT, Ghent University, Ghent, Belgium; 2Department of Neuroradiology, Ghent University Hospital, Ghent, Belgium

We propose a new algorithm for cortical thickness measurement in T1 weighted (T1-w) MRI images aiming to overcome the major limitation of a number of the existing similar methods which could lead to under- or over-estimated thickness of grey matter within sulci: (1) lack of awareness of the partial volume (PV) effect (the presence of multiple tissue classes in a single voxel) present at both the white matter (WM) to gray matter (GM) and the GM to cerebrospinal fluid (CSF) transition, and (2) ignorance of the regions of buried cortex where the CSF between the sulci is not resolved.