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Abstract #3207

Multiparametric Assessment of Healthy & OA Articular Cartilage Under Loading at 17.6 T

Jose G. Raya1, Gerd Melkus2, Silvia Adam-Neumair3, Kevin Dunham, Olaf Dietrich3, Maximilian F. Reiser3, Reinhard Putz3, Peter M. Jakob4, Christian Glaser

1Radiology, New York University Langone Medical Center, New York, NY, United States; 2University of California, San Francisco; 3University of Munich; 4University of Wuerzburg

The aim of this work was to characterize the functionality of human healthy and OA articular cartilage using a multiparametric approach (T2, T1, ADC, FA and water volume fraction). Samples of healthy (n=10) and OA (n=3) patellar cartilage were MRI examined at 17.6T (resolution=50100μm2) native, under loading (strain=26%) and 4h after relaxation (n=5 healthy, n=1 OA). Differences in MRI parameters between the native and loading examinations were larger in absolute value and extension in OA than in the healthy samples. After 4h relaxation, healthy samples returned to their native values, whereas the OA sample demonstrated signs of the indentation.