A Newly Strictly Non-Invasive Experimental Device Allowing Repeated MR Investigations of Exercising Hindlimb Mouse Muscles at Ultra-High Field (11.75T)

Julien Gondin¹, Christophe Vilmen¹, Patrick J. Cozzone¹, Guillaume Duhamel¹, David Bendahan¹

We have constructed a strictly non-invasive experimental setup adapted to an ultra-high field MR system and report in the present work the results of MRI investigation and force production measurements in exercising hindlimb mouse muscles at ultra-high field. This newly strictly non-invasive device allowed highly reproducible measurements of both force production and muscle activation (T2 changes) in exercising hindlimb mouse muscles within an ultra-high field magnet. Our setup appears as a suitable tool for future ultra-high field functional MR investigations of exercising hindlimb mouse muscles.