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Abstract #3208

A Newly Strictly Non-Invasive Experimental Device Allowing Repeated MR Investigations of Exercising Hindlimb Mouse Muscles at Ultra-High Field (11.75T)

Julien Gondin1, Christophe Vilmen1, Patrick J. Cozzone1, Guillaume Duhamel1, David Bendahan1

1Centre de Rsonance Magntique Biologique et Mdicale (CRMBM) - UMR CNRS 6612, Facult de Mdecine - Universit de la Mditerrane, Marseille, France

We have constructed a strictly non-invasive experimental setup adapted to an ultra-high field MR system and report in the present work the results of MRI investigation and force production measurements in exercising hindlimb mouse muscles at ultra-high field. This newly strictly non-invasive device allowed highly reproducible measurements of both force production and muscle activation (T2 changes) in exercising hindlimb mouse muscles within an ultra-high field magnet. Our setup appears as a suitable tool for future ultra-high field functional MR investigations of exercising hindlimb mouse muscles.