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Abstract #3220

Quantitative Cartilage Degeneration Associated with Spontaneous Osteoarthritis in a Guinea Pig Model

Matthew Fenty1, Victor Babu Kassey1, George Dodge2, Ari Borthakur1, Ravinder Reddy1

1CMROI, Radiology, University of Pennsylvania, Philadelphia, PA, United States; 2McKay Orthopaedics Labs, Department of Orthopaedic Surgery, University of Pennsylvania School of Medicine, Philadelphia, PA, United States

Osteoarthritis (OA) is a common and painful condition with a multi-factorial etiology of the musculoskeletal system affecting more than 50% of the U.S. population over 65. Degeneration of the articular cartilage, which is believed to be a primary factor in the development of OA, is a slow process and typically takes decades to have full thickness loss. Dunkin-Hartley guinea pigs have been shown to develop OA with the earliest stage of detection manifesting as early as three to four months of age. T MRI has been shown to correlate with cartilage proteoglycan content. However, there have been no T MRI studies in the Dunkin-Hartley guinea pig model with naturally occurring joint disease that closely mimics human OA. The aim of this study is to quantify age-dependent cartilage degeneration via T MRI with verification by histopathology measurements.