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Abstract #3489

Whole Brain MRE with Guided Pressure Waves

Xavier Maitre1, Emeline Lamain1, Ralph Sinkus2, Bruno Louis3, Luc Darrasse1

1IR4M (UMR8081), Univ Paris-Sud, CNRS, Orsay, France; 2Centre de Recherches Biomedicales Bichat-Beaujon (UMR773), CRB3, Inserm, Paris, France; 3Biomecanique Cellulaire et Respiratoire (U841), IMRB, Inserm, Creteil, France

For a given acquisition sequence, the sensitivity of MR-elastography relies on the strength of the shear waves which may be induced in the targeted organ. For the last ten years, the brain has proven to be rather well decoupled from any mechanical excitations by the natural shielding layers. A very different approach from current devices was taken here. By guiding pressure waves into the buccal cavity, it was possible to generate, throughout the brain, shear waves in the three directions such that whole brain MRE could be performed and 3D maps of dynamic and loss shear moduli could be reconstructed.