Abhishek Yadav1, Rakesh Kumar Gupta1,
Santosh Kumar Yadav1, M Rangan2, V. A. Saraswat3,
M. A. Thomas4, R. K. S. Rathore5
1Radiodiagnosis, Sanjay
Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India, Lucknow,
Uttar Pradesh, India; 2Pediatric Gastroenterology, Sanjay Gandhi
Post Graduate Institute of Medical Sciences,
Lucknow, India, Lucknow, UP, India; 3Pediatric
Gastroenterology, Sanjay Gandhi Post Graduate Institute of Medical
Sciences, Lucknow, India, lucknow, UP,
India; 4Department of Radiological Sciences, Sanjay Gandhi Post
Graduate Institute of Medical Sciences,
Lucknow, India, California, Los Angels, United States; 5Department
of Mathematics & Statistics, Indian Institute of Technology, Kanpur, UP,
India
Acute-on-chronic liver (ACLF) failure develops in patients with previously well-compensated chronic liver disease following an acute precipitating event. It is known that the cerebral autoregulation may be defective in patients of liver failure, and raised ICP is often seen in ALF patients. Ammonia and cytokines are known to increase in ACLF, and have synergistic role in pathogenesis of HE. The current data suggest that ASL demonstrates the increase in CBF various grey matter regions in ACLF and may be used in the in initial and follow up study of these ACLF patients.