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Abstract #4261

Diffusion Tensor Invasive Phenotypes Can Predict Time to Progression in Glioblastomas

Laila A. Mohsen1,2, Veronica Shi3, Rajesh Jena4, Jonathan H. Gillard1, Stephen J. Price3,5

1University Department of Radiology, University of Cambridge, Cambridge, United Kingdom; 2Radiology Department, Al-Menia University, Al-Menia, Egypt; 3Neurosurgery Division, Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom; 4Department of Oncology, Addenbrooke's Hospital, Cambridge, United Kingdom; 5Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, United Kingdom

Invasion of the surrounding brain is a key feature of glioblastomas and major cause of treatment failure. The degree of invasion varies in individuals. We have assessed the invasive phenotype of 21 glioblastoma patients receiving similar treatment using the pq decomposition method. We have shown that 20% of patients have a minimally invasive phenotype. These patients have a longer time to progression and are more likely to be progression free at 18 months than the other subtypes.