Temporally-Resolved Imaging of Renal Sodium-23 Changes After Furosemid Injection

Raffi Kalayciyan¹, Friedrich Wetterling¹, Sabine Neudecker², Norbert Gretz², Lothar R. Schad¹

Since renal function is highly correlated with renal tissue 23Na concentration, 23Na-Kidney-MRI can be used to monitor the spatial changes in 23Na along the corticomedullary axis after diuretics administration. Furthermore, the temporal changes in the medulla and cortex 23Na signals could be studied, if sufficient spatial and temporal resolution can be achieved. The aim of this study was to measure the temporal 23Na signal before and after furosemide-injection in four rats via bilateral renal 23Na-MRI (n=8). In order to maximize 23Na signal at 9.4 T, a 3D-Ultrashort Echo Time (3D-UTE) sequence was used in conjunction with a home-built transceiver surface resonator.