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Abstract #0354

In Vivo Investigation of Restricted Diffusion in Human Brain Using Oscillating Diffusion Gradients

Anh Tu Van1, Samantha J. Holdsworth1, Roland Bammer1

1Center for Quantitative Neuro Imaging, Radiology, Stanford University, Palo Alto, CA, United States

Cosine-modulated diffusion gradients were used in combination with tetrahedral diffusion encoding to achieve the minimum diffusion time of 4 ms at an acceptable b-value and echo time on a standard 3 T human MRI system. At these short diffusion times, on three healthy volunteers, the measured ADCs at the genu of the corpus callosum start to show the time dependent characteristic of restricted diffusion.