Abstract #1571

Magnetic-Resonance Analysis of Dynamic Permeability Change in Focused-Ultrasound Induced Blood-Brain Barrier Disruption in Small Animals

Wen-Yen Chai¹,², Po-Chun Chu³, Yu-Chun Lin¹, Jiun-Jie Wang⁴, Yau-Yau Wai¹, Tzu-Chen Yen, Hao-Li Liu³

¹Department of Diagnostic Radiology, Chang Gung Memorial Hospital Linkou, Taoyuan, Taiwan; ²Department of Electrical Engineering, Chang-Gung University, Taoyuan, Taiwan; ³Department of Electrical Engineering, Chang-Gung University, Taoyuan, Taiwan; ⁴Department of Medical Image and Radiological Sciences, Chang-Gung University

Microbubble-enhanced burst-mode focused ultrasound (FUS) can disrupt the blood-brain barrier (BBB), and only sustained for a limited duration (usually a few hours). Two DSC-MRI were acquired at 10/150 mins after sonication to generate two permeability maps Ktrans/ Ve. The mean values of Ktrans/ Ve. at 150 mins. were obviously decrease 60% /64% when compared with 10 mins. This implies the local permeability change induced from FUS-induced BBB-disruption were highly dynamic.