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Abstract #1572

In-Vivo Temporal Characterization of Focal Openings of the Blood-Brain Barrier Using MR Guided Focused Ultrasound

Andreia Silva1, 2, Angelika Hoffmann1, Alexander Klibanov1, Max Wintermark1, Sara Reis1, John Mugler III1, Jaime Mata1

1Radiology & Medical Imaging, University of Virginia, Charlottesville, VA, United States; 2IBEB -FCUL, Universidade de Lisboa, Lisboa, Portugal

The use of contrast agents and therapeutic agents in the brain is limited by the blood-brain barrier (BBB), which restricts their entry into the brain. Focal or regional opening of the BBB in a non-invasive and controlled way may provide the administration of specifically targeted therapeutic agents to a localized area.