Abstract #1572

In-Vivo Temporal Characterization of Focal Openings of the Blood-Brain Barrier Using MR Guided Focused Ultrasound

Andreia Silva¹,², Angelika Hoffmann¹, Alexander Klibanov¹, Max Wintermark¹, Sara Reis¹, John Mugler III¹, Jaime Mata¹

¹Radiology & Medical Imaging, University of Virginia, Charlottesville, VA, United States; ²IBEB -FCUL, Universidade de Lisboa, Lisboa, Portugal

The use of contrast agents and therapeutic agents in the brain is limited by the blood-brain barrier (BBB), which restricts their entry into the brain. Focal or regional opening of the BBB in a non-invasive and controlled way may provide the administration of specifically targeted therapeutic agents to a localized area.