Po-Chun Chu1, Wen-Yen Chai1, 2, Jiun-Jie Wang3, Tzu-Chen Yen4, Hao-Li Liu1
1Department of Electrical Engineering, Chang-Gung University, Taoyuan, Taiwan, Taiwan; 2Department of Diagnostic Radiology, Chang-Gung University and Memorial Hospital, Linkou, Taiwan, Taiwan; 3Department of Medical Image and Radiological Sciences, Chang-Gung University, Taoyuan, Taiwan, Taiwan; 4Molecular Imaging Center, Chang-Gung University and Memorial Hospital, Linkou, Taiwan, Taiwan
We use magnetic-resonance relaxivity technology to perform quantitative PK/PD analysis of small molecule in BBB animal model. Area-under-curve (AUC) map were then transferred from a series of time-dependent R1 maps to perform PD characteristic of Gd-DTPA in order to reflect Evans blue permeate dynamics. The analyzed accumulated R1 relaxivity provide high correlation with the Evans blue, implies that the R1-based pharmacodynamic analysis provide reasonable mapping to the permeability of the Evans blue into the BBB-disrupted region. This study provides an improved quantitative MR protocol for analyze the therapeutic molecule leakage when using focused ultrasound to induce BBB disruption for future brain drug delivery.
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