Abstract #1832

Measurement of Apparent Diffusion Coefficients (ADC) and 1H Transverse Relaxation Times (T2) of Human Brain Metabolites and Water: Insights on White Matter Microstructure

Francesca Branzoli¹, Aranee Techawiboonwong², Andrew Webb¹, Itamar Ronen¹

¹C. J. Gorter Center for High Field MRI, Department of Radiology, Leiden University Medical Center, Leiden, Netherlands; ²Department of Electrical Engineering, Mahidol University, Bangkok, Thailand

The phenomenon of diffusion of molecules in biological tissues directly relates to the characteristic length scales of tissue compartments and it has been recognized as a powerful contrast mechanism for deriving information on white matter microstructure. In this study, for the first time the interaction between proton transverse relaxation times (T2) and apparent diffusion coefficients (ADC) was investigated, by means of diffusion-weighted spectroscopy, for both water and metabolites in the human brain at 7T.