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Abstract #3564

Double Wave Vector Diffusion Weighting in Wallerian Degeneration

Martin A. Koch1, 2, Jrgen Finsterbusch1

1Systems Neuroscience, Neuroimage Nord, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; 2Institute of Medical Engineering, University of Lbeck, Lbeck, Germany

Double wave vector diffusion weighting is a new approach for assessing tissue characteristics such as mean pore size and shape: for restricted diffusion the MR signal acquired with two successive diffusion weighting periods may depend on the angle between the two applied gradient directions. At short mixing times, the signal difference between parallel and antiparallel gradient orientations can be related to the mean pore size. It is investigated whether the size estimate derived from this signal difference is sensitive to pathological changes in the tissue microstructure of the corticospinal tracts.