Abstract #0093

Derivation and Comparison of Site Specific Peripheral and Transition Zone Quantitative DCE MRI Logistic Regression Models for Prostate Cancer Detection: Does Cancer Location Matter?

Nikolaos Dikaios¹, Mohamed Abd Alazeez², Mark Emberton², Taiki Fujiwara³, David Atkinson⁴, Shonit Punwani⁴

¹Centre for Medical Imaging, University College London , London, Greater London, United Kingdom; ²Department of Urology, University College London Hospital, London, Greater London, United Kingdom; ³Department of Radiology, University College London Hospital, London, Greater London, United Kingdom; ⁴Centre for Medical Imaging, University College London, London, Greater London, United Kingdom

Dynamic contrast enhancement (DCE) MRI has been advocated for detection of prostate cancer, but studies predominantly concentrate on peripheral zone tumours. Biological differences are known to exist between tumours within transition and peripheral zones due to their different microenvironment. This study aims to compare and contrast quantitative DCE MRI parameters of prostate PZ and TZ cancer and non-cancer regions; to identify those best able to classify cancer tissue at each site and thereby improve DCE MRI based diagnostic models used within computer aided detection software.