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Abstract #1267

Effect of Manganese on Rat Hippocampus Metabolism: A 1H HRMAS Study

Alexia Daoust1, 2, Emmanuel Luc Barbier1, 2, Sylvain Bohic1, 3, Sverine Maunoir-Regimbal4, Florence Fauvelle4

1INSERM U836, grenoble, France; 2Universit Joseph Fourier, Grenoble institut des neurosciences, grenoble, France; 3European Synchrotron Radiation Facility, grenoble, France; 4IRBA-CRSSA, grenoble, France

MEMRI can be used for different applications such as tracing neuronal connections or functional imaging. However, the impact of Mn on brain tissues is still unclear. To evaluate the metabolic perturbations associated to an intracerebral injection of Mn, we obtained HRMAS NMR spectra from the rat hippocampus. Two effects were observed: a broadening of specific metabolites due to Mn paramagnetic effect and an important impact of Mn on the cerebral metabolism at the injection site. Both effects were not identical along hippocampus and across hemisphere, suggesting a concentration dependent effect.