Samata Kakkad1, 2, Jiangyang Zhang3, Alireza Akhbardeh1, Meiyappan Solaiyappan1, Venu Raman1, Dieter Leibfritz2, Kristine Glunde4, Zaver M. Bhujwalla4
1JHU ICMIC Program, Division of Cancer Imaging Research, The Johns Hopkins University SOM, Baltimore, MD, United States; 2Department of Chemistry and Biology, University of Bremen, Bremen, Germany; 3Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University SOM, Baltimore, MD, United States; 4JHU ICMIC Program, Division of Cancer Imaging Research, Johns Hopkins University, Baltimore, MD, United States
Hypoxic tumor microenvironments are frequently observed in tumors and are associated with an aggressive phenotype and resistance to radiation and chemotherapy. We previously observed significantly fewer collagen fibers in hypoxic tumor regions. Diffusion tensor imaging is often used to distinguish between normal, benign and malignant breast tissue as a non-contrast imaging technique, since lower water diffusion and diffusion anisotropy parameters are observed in malignant tissue. Here we examined the relationship between low collagen containing hypoxic tumor regions and high resolution DTI and observed lower diffusion and diffusion anisotropy in hypoxic regions compared to normoxic regions within a breast cancer xenograft.