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Abstract #1711

Chemical Shift Imaging Application of Tagitinin C Antimetastatic Activity in Xenograft Models of Hepatocellular Carcinoma

Chi-Long Juang1, Chuan-Yi Lin1, 2, Sheng-Ching Liu3, Chi-Yu Yang4, Hsiao-Chuan Wen1

1Department of Radiological Technology, Yuanpei University, Hsin Chu, Taiwan; 2Department of Medical Imaging, Buddhist Tzu Chi General Hospital, New Taipei, Taiwan; 3Department of Radiology, Hsinchu Mackay Memorial Hospital, Hsin Chu, Taiwan; 4Division of Animal Medicine, Animal Technology Institute Taiwan, Miaoli, Taiwan

Tagitinin C, a major sesquiterpenoid, was isolated from the leaves of Tithonia diversifolia and was identified of its anti-hepatoma ability in our previous data. In this study the anti-metastasis ability of tagitinin C in xenograft models of Hep-G2 carcinoma was investigated by chemical shift imaging (CSI). Our results showed that tumor cells spread throughout all parts of the abdomen and metastasized to many organs of the mice after 5-25 days inoculation. We also found that tagitinin C can not only reduce the choline/creatine level but also keep most of the choline appeared near by the inoculated point.