Associations with Disease Free Survival and Pre Treatment Texture Features Obtained from Dynamic Contrast Enhanced Breast Images

Martin D. Pickles¹, Peter Gibbs¹, Martin Lowry¹, Lindsay W. Turnbull¹

The aim of this work was to determine if there were any associations between pre-treatment MR derived texture parameters with disease free survival (DFS), in a cohort of patients whom had undergone neoadjuvant chemotherapy. Significant associations between MR texture parameters and survival intervals were noted. Moreover when intercorrelations between variables were considered via a Coxs proportional hazards model only two variables were retained, sum entropy (texture) and MR longest diameter. In conclusion, texture features provide an insight into longer term DFS and for this cohort texture features out performed DCE-MRI parameters and traditional prognostic indicators.