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Abstract #4486

Quantification of Left Ventricular Twist During Free-Breathing with SPAtial Modulation of Magnetization (SPAMM) and Fourier Analysis of STimulated Echoes (FAST)

Meral L. Reyhan1, 2, Hyun Grace Kim1, Daniel B. Ennis1, 2

1Department of Radiological Sciences, University of California Los Angeles, Los Angeles, CA, United States; 2Biomedical Physics Interdepartmental Program, University of California Los Angeles, Los Angeles, CA, United States

Left Ventricular (LV) twist is an imaging biomarker for global LV dysfunction, which is often measured from breath-held tagged cardiac MRI. We hypothesized that significant differences exist in LV twist measurements derived from images acquired during breath-holding, free-breathing with averaging, and respiratory bellows gated free-breathing. Bellows derived estimates of LV twist were significantly lower than breath-held. No significant differences in LV twist were detected between breath-held and free-breathing with averaging. Breath-held consistency can be variable during clinical studies, therefore bellows gating may be a more accurate biomarker of LV dysfunction in patients with limited breath-hold capabilities.