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Abstract #4487

Analysis of Neonatal Cardiac Function in Infants with and Without Patent Ductus Arteriosus

Kathryn M. Broadhouse1, 2, Anthony N. Price1, 2, Giuliana Durighel1, Anna E. Finnemore1, 2, David J. Cox1, A. David Edwards1, 2, Joseph V. Hajnal1, 2, Alan M. Groves1, 2

1Imaging Sciences Department, MRC Clinical Sciences Centre, Imperial College, London, United Kingdom; 2The Centre for the Developing Brain, Imaging Sciences & Biomedical Engineering Division, King's College, London, United Kingdom

The aim of this study was to quantify ventricular dimension and function in healthy neonates. Then compare patent ductus arteriosus (PDA) infants to this normative range to determine the impact of shunt volume. 2D SSFP stacks providing full coverage of the left ventricle were acquired in neonates with and without PDA to assess the impact of shunt volume on left ventricular morphology and function. Shunt volume was calculated from phase contrast sequences acquired during the same MRI scan. Although left ventricular output and left ventricular mass were significantly increased in PDA infants, ejection fraction remained within the normal range.