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Abstract #0075

Molecular MRI detection of the brain development in normal children with magnetization transfer (MT) and amide proton transfer (APT) imaging

Hong Zhang 1,2 , Xuna Zhao 3 , Jinyuan Zhou 2 , and Yun Peng 4

1 Imaging Center,Beijing Childrens Hospital, Capital Medical University, Beijing, China, 2 Neurosection, Division of MR Research, Department of Radiology, Johns Hopkins University, Baltimore, MD, United States, 3 Peking University, Beijing, China, 4 Beijing Childrens Hospital, Capital Medical University, Beijing, China

MT-MRI is sensitive to a semi-solid macromolecular phase in tissue, and APT-MRI is sensitive to the amide protons of mobile proteins and peptides, both accomplishing detection using the water signal. We detected brain development patterns in normal children using MT and APT imaging at 3T. Our preliminary results showed that MTRasym(3.5ppm) decreased exponentially and MTR increased exponentially with age, with the most significant changes occurring within the first 2 years of life. MT and APT imaging may be useful to assess the progress of myelination.

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