Abstract #0796
Rotating field gradient (RFG) MR for direct measurement of the diffusion orientation distribution function (dODF)
Evren Ozarslan 1 , Alexandru V Avram 2 , Peter J Basser 2 , and Carl-Fredrik Westin 1
1
Department of Radiology, Brigham and Women's
Hospital, Harvard Medical School, Boston, MA, United
States,
2
Section
on Tissue Biophysics and Biomimetics, PPITS, NICHD,
National Institutes of Health, Bethesda, MD, United
States
Rotating field gradients (RFGs), generated by applying
sine- and cosine-modulated gradient waveforms along two
perpendicular directions, provide an alternative
diffusion sensitization mechanism for MRI. Two RFGs with
a 90 degree phase shift, applied around the 180 degree
RF pulse in a spin echo sequence can be used to measure
the dODF directly, obviating the need to transform the
data from a space reciprocal to the displacement space.
Experiments on an asparagus specimen performed on a
clinical scanner confirmed the predicted signal
dependence in anisotropic environments.
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