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Abstract #0796

Rotating field gradient (RFG) MR for direct measurement of the diffusion orientation distribution function (dODF)

Evren Ozarslan 1 , Alexandru V Avram 2 , Peter J Basser 2 , and Carl-Fredrik Westin 1

1 Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States, 2 Section on Tissue Biophysics and Biomimetics, PPITS, NICHD, National Institutes of Health, Bethesda, MD, United States

Rotating field gradients (RFGs), generated by applying sine- and cosine-modulated gradient waveforms along two perpendicular directions, provide an alternative diffusion sensitization mechanism for MRI. Two RFGs with a 90 degree phase shift, applied around the 180 degree RF pulse in a spin echo sequence can be used to measure the dODF directly, obviating the need to transform the data from a space reciprocal to the displacement space. Experiments on an asparagus specimen performed on a clinical scanner confirmed the predicted signal dependence in anisotropic environments.

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