Rotating field gradient (RFG) MR for direct measurement of the diffusion orientation distribution function (dODF)
Evren Ozarslan 1 , Alexandru V Avram 2 , Peter J Basser 2 , and Carl-Fredrik Westin 1
Department of Radiology, Brigham and Women's
Hospital, Harvard Medical School, Boston, MA, United
on Tissue Biophysics and Biomimetics, PPITS, NICHD,
National Institutes of Health, Bethesda, MD, United
Rotating field gradients (RFGs), generated by applying
sine- and cosine-modulated gradient waveforms along two
perpendicular directions, provide an alternative
diffusion sensitization mechanism for MRI. Two RFGs with
a 90 degree phase shift, applied around the 180 degree
RF pulse in a spin echo sequence can be used to measure
the dODF directly, obviating the need to transform the
data from a space reciprocal to the displacement space.
Experiments on an asparagus specimen performed on a
clinical scanner confirmed the predicted signal
dependence in anisotropic environments.
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