Cellular Size Distributions Revealed by Non-Uniform Oscillating-Gradient Spin-Echo (NOGSE) MRI

Noninvasively characterizing cellular size distributions is paramount since their features impact underlying functional or biological capacities. Herein, we harness Non-uniform-Oscillating-Gradient Spin-Echo Magnetic-Resonance-Imaging (NOGSE MRI) a methodology probing diffusion dynamics with extraordinary sensitivity towards compartmental dimensions for depicting size distributions in a simple, one-dimensional experiment. Simulations and experiments in yeast cells validate NOGSEs ability to faithfully reconstruct cellular size distributions; NOGSE-derived maps of size distribution properties in the mouse brain reveal hallmark microstructural features in both white and gray matter. NOGSEs exquisite sensitivity towards length to the power of six renders it highly promising for contrasting disease in-vivo from size distribution contrast.

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