Abstract #0803
Grid structure of brain pathways Validation and the character of turns
Van Jay Wedeen 1 , Farzad Mortazavi 2 , Ruopeng Wang 1 , Wen-Yih Isaac Tseng 3 , Thomas Witzel 1 , Aapo Nummenmaa 1 , William Morrison 4 , H Eugene Stanley 4 , Lawrence Wald 1 , and Douglas Rosene 2
1
Radiology, Massachusetts General Hospital,
Charlestown, MA, United States,
2
Anatomy
and Neurobiology, Boston University, Boston, MA, United
States,
3
Center
for Optoelectronic Biomedicine, National Taiwan
University, Taipei, Taiwan,
4
Boston
Unviersity, Boston, United States
Recently it has been found that the fiber pathways of
the brain follow a curvilinear grid derived from the
three axes of development. Here we present a method to
objectively identify this structure among the brain
pathways. For each voxel and pair of diffusion ODF
maximum vectors, arrays of parallel crossing paths are
constructed, and retained only where they form a 2D
surface. In rhesus DSI, grid structure was demonstrated
explicitly and extensively. In gyri, the preponderance
of pathways followed rectilinear grid trajectories.
These studies show grid structure can be objectively
defined, and promise new quantitative strategies for MRI
tractography.
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