Abstract #0804
Anatomical Accuracy of Diffusion MRI Tractography: Testing the Fundamental Limits
Cibu P Thomas 1,2 , Frank Q Ye 3 , Mustafa Okan Irfanoglu 1,2 , Pooja D Modi 1 , Kadharbatcha S Saleem 3 , David A Leopold 3 , and Carlo Pierpaoli 1
1
National Institute of Child Health and Human
Development, Bethesda, Maryland, United States,
2
Center
for Neuroscience and Regenerative Medicine, USUHS,
Bethesda, Maryland, United States,
3
National
Institute of Mental Health, Bethesda, Maryland, United
States
Although tractography based on diffusion-weighted
magnetic resonance imaging (DWI) is a widely used
technique for mapping the structural connections of the
brain in vivo, its anatomical accuracy is highly
questionable. It is generally assumed that this
limitation can be resolved if DWI data with sufficiently
high spatial and angular resolution and superior signal
to noise ratio (SNR) can be acquired. Here, we report
that despite using DWI data of unprecedented quality
none of the tractography techniques we tested
consistently showed superior anatomical accuracy. These
results suggest that the quest for an optimal diffusion
tractography technique may be elusive.
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