Proton diffusion tensor spectroscopy of metabolites in human muscle in vivo

Purpose: To study apparent diffusivity and directionality for metabolites of skeletal muscle in humans by 1H-MRS. Methods: Diffusion tensors in tibialis anterior muscle oriented at the magic angle were determined at 3T using optimized methods including an adapted STEAM sequence and simultaneous fitting. Results: Apparent diffusivities and fractional anisotropies of taurine, creatine, trimethylammonium compounds, carnosine and water were estimated. The diffusivities of most metabolites and water were significantly different from each other. Diffusion was found to be anisotropic and the diffusion tensors to be essentially coaligned. Magnitudes of the diffusivities were largely ordered according to molecular weight.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.