Abstract #0827
Skeletal Muscle Metabolism Measured by Hyperpolarized 13C MR Spectroscopy
Jae Mo Mo Park 1 , Sonal Josan 1 , Dirk Mayer 2 , Ralph Hurd 3 , David Bendahan 4 , Daniel Spielman 1 , and Thomas Jue 5
1
Radiology, Stanford University,
Stanford, CA, United States,
2
Diagnostic
Radiology and Nuclear Medicine, University of
Maryland, Baltimore, MD, United States,
3
GE
Healthcare, Menlo Park, CA, United States,
4
Centre
de Resonance Magnetique Biologique et Medicale,
Marseille, United States,
5
Biochemistry,
UC Davis, Davis, CA, United States
In this study, we have directly followed
hyperpolarized [1-13C]lactate in rat leg muscle
in vivo to confirm that muscle can indeed
metabolize exogenous lactate. Metabolic dynamics
and 3D images were acquired at baseline and 1h
after dichloroacetate. The fate of acetyl-CoA in
mitochondria was further investigated using
hyperpolarized [2-13C]pyruvate. The radically
increased 13C-bicarbonate peak indicates
pyruvate dehydrogenase (PDH) activation and a
potential participation of lactate in the TCA
cycle to support oxidative phosphorylation.
Moreover, [2-13C]pyruvate experiment confirms
that the up-regulated PDH activity results in
increased pyruvate flow into the TCA cycle.
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