Differentiation of Brown Adipose Tissue using Manganese Enhanced MRI

Manganese-enhanced MRI (MEMRI) is a useful method for measuring calcium-dependent cellular activity due to accumulation of Mn2+ in cells via voltage-gated calcium channels. We investigated the feasibility of MEMRI as a method to detect BAT activation in mice induced by cold exposure. We show for the first time that MEMRI can differentiate between BAT and WAT tissue in mice.

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