Abstract #1087
CEST imaging of human breast cancer cells
Catherine DeBrosse 1 , Mohammad Haris 1 , Ravi Prakash Reddy Nanga 1 , Hari Hariharan 1 , Damodar Reddy 1 , Imran Mohammad 2 , Kejia Cai 1 , Anup Singh 1 , and Ravinder Reddy 1
1
Center for Magnetic Resonance and Optical
Imaging, Department of Radiology, University of
Pennsylvania, Philadelphia, Pennsylvania, United States,
2
Department
of Pharmacology and Institute for Translational Medicine
and Therapeutics, University of Pennsylvania,
Philadelphia, Pennsylvania, United States
The purpose of this study was to determine feasibility
of glutamate chemical exchange saturation transfer
(GluCEST) imaging in human breast cancer cell lines
treated with poly-L-glutamate (PLG). PLG has been used
as a drug-conjugate in recently developed cancer
therapies, as it is broken down by tumor proteases.
Glutamate fragments that result from PLG degradation
have labile amine protons that exchange with water and
give GluCEST signal. In this study, we demonstrate that
treatment of human breast cancer cells with PLG led to
an increase in GluCEST signal due to the breakdown of
PLG by tumor proteases such as cathepsins.
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