Abstract #1089
Role of Lymphatic Endothelial Cells in Prostate Cancer Cell Invasion in Tumor Microenvironments
Tariq Shah 1 , Flonne Wildes 1 , Dmitri Artemov 1 , and Zaver M Bhujwalla 1
1
Division of Cancer Imaging Research,
Department of Radiology and Radiological Sci, Johns
Hopkins University, Baltimore, Maryland, United States
While the presence of lymph node metastasis as a major
prognosticator for many cancers, including prostate
cancer, is well established, the regulation of
tumor-associated lymphangiogenesis and the
microenvironmental factors that affect the invasion of
cancer cells into lymphatic vessels requires additional
investigation. Here we have investigated the role of
lymphatic endothelial cells prostate-cancer cell
interaction in the invasion and degradation of the
extracellular matrix (ECM) under normoxic and hypoxic
environments using our MR compatible cell perfusion
assay, and determined the associated metabolic changes.
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