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Abstract #1089

Role of Lymphatic Endothelial Cells in Prostate Cancer Cell Invasion in Tumor Microenvironments

Tariq Shah 1 , Flonne Wildes 1 , Dmitri Artemov 1 , and Zaver M Bhujwalla 1

1 Division of Cancer Imaging Research, Department of Radiology and Radiological Sci, Johns Hopkins University, Baltimore, Maryland, United States

While the presence of lymph node metastasis as a major prognosticator for many cancers, including prostate cancer, is well established, the regulation of tumor-associated lymphangiogenesis and the microenvironmental factors that affect the invasion of cancer cells into lymphatic vessels requires additional investigation. Here we have investigated the role of lymphatic endothelial cells prostate-cancer cell interaction in the invasion and degradation of the extracellular matrix (ECM) under normoxic and hypoxic environments using our MR compatible cell perfusion assay, and determined the associated metabolic changes.

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