Abstract #2656
Evaluation of the Effect of Intra-voxel Contrast Agent Diffusion on Quantitative DCE-MRI
Stephanie L. Barnes 1,2 , Natenael B. Semmineh 1,3 , C. Chad Quarles 1,2 , and Thomas E. Yankeelov 1,2
1
Vanderbilt University Institute of Imaging
Sciences, Vanderbilt University, Nashville, TN, United
States,
2
Radiology
and Radiological Sciences, Vanderbilt University,
Nashville, TN, United States,
3
Physics
and Astronomy, Vanderbilt University, Nashville, TN,
United States
Standard evaluation of dynamic contrast enhanced MRI
(DCE-MRI) data assumes instantaneous mixing of the
contrast agent (CA) within a given voxel. This work aims
to evaluate the effect of non-instantaneous mixing due
to passive diffusion of the CA on quantitative DCE-MRI.
We utilized a finite element model of a (250 m
2
)
voxel that divides the voxel into vascular,
extravascular extracellular, and extravascular
intracellular spaces. The results show that diffusion,
plasma fraction, and temporal resolution have a
substantial effect on the distribution of CA
concentration and this can significantly affect the
estimation of pharmacokinetic parameters.
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