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Abstract #2656

Evaluation of the Effect of Intra-voxel Contrast Agent Diffusion on Quantitative DCE-MRI

Stephanie L. Barnes 1,2 , Natenael B. Semmineh 1,3 , C. Chad Quarles 1,2 , and Thomas E. Yankeelov 1,2

1 Vanderbilt University Institute of Imaging Sciences, Vanderbilt University, Nashville, TN, United States, 2 Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, United States, 3 Physics and Astronomy, Vanderbilt University, Nashville, TN, United States

Standard evaluation of dynamic contrast enhanced MRI (DCE-MRI) data assumes instantaneous mixing of the contrast agent (CA) within a given voxel. This work aims to evaluate the effect of non-instantaneous mixing due to passive diffusion of the CA on quantitative DCE-MRI. We utilized a finite element model of a (250 m 2 ) voxel that divides the voxel into vascular, extravascular extracellular, and extravascular intracellular spaces. The results show that diffusion, plasma fraction, and temporal resolution have a substantial effect on the distribution of CA concentration and this can significantly affect the estimation of pharmacokinetic parameters.

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