Evaluation of the Effect of Intra-voxel Contrast Agent Diffusion on Quantitative DCE-MRI
Stephanie L. Barnes 1,2 , Natenael B. Semmineh 1,3 , C. Chad Quarles 1,2 , and Thomas E. Yankeelov 1,2
Vanderbilt University Institute of Imaging
Sciences, Vanderbilt University, Nashville, TN, United
and Radiological Sciences, Vanderbilt University,
Nashville, TN, United States,
and Astronomy, Vanderbilt University, Nashville, TN,
Standard evaluation of dynamic contrast enhanced MRI
(DCE-MRI) data assumes instantaneous mixing of the
contrast agent (CA) within a given voxel. This work aims
to evaluate the effect of non-instantaneous mixing due
to passive diffusion of the CA on quantitative DCE-MRI.
We utilized a finite element model of a (250 m
voxel that divides the voxel into vascular,
extravascular extracellular, and extravascular
intracellular spaces. The results show that diffusion,
plasma fraction, and temporal resolution have a
substantial effect on the distribution of CA
concentration and this can significantly affect the
estimation of pharmacokinetic parameters.
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