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Abstract #2680

Assessing microstructural substrates of white matter abnormalities using NODDI - application to a metabolic disease

Inge Timmers 1,2 , Alard Roebroeck 1 , Matteo Bastiani 1,3 , Bernadette Jansma 1 , Estela Rubio-Gozalbo 2 , and Hui Zhang 4

1 Department of Cognitive Neuroscience, Maastricht University, Maastricht, Netherlands, 2 Department of Pediatrics, Maastricht University Medical Center, Maastricht, Netherlands, 3 Institute of Neuroscience and Medicine, Forschungszentrum Juelich GmbH, Juelich, Germany, 4 Department of Computer Science & Centre for Medical Image Computing, University College London, London, United Kingdom

This work demonstrates neurite orientation dispersion and density imaging (NODDI) as a tool for investigating microstructural substrates of white matter abnormalities in a clinical population. NODDI estimates indices of neurite density (NDI) and orientation dispersion (ODI), two key contributors of fractional anisotropy (FA) from diffusion tensor imaging (DTI). We show that NODDI analysis of multi-shell diffusion-weighted data adds microstructural specificity to the findings from DTI. Findings from the NODDI indices overlap substantially with FA, revealing the specific microstructural changes corresponding to the latter. We additionally demonstrate that NODDI analysis of single-shell data can potentially be used for detecting ODI changes.

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