Enhanced contrast of punctuate paramagnetic structures through zero-padding
Clemens Diwoky 1 , Daniel Liebmann 2 , Dirk Strunk 3 , and Rudolf Stollberger 1
Graz University of Technology, Graz,
Cell Research Unit, Dept. of Hematology, Univ. Clinic of
Internal Medicine, Medical University of Graz, Graz,
Experimental and Clinical Cell
Therapy Institute, Paracelsus Medical University,
Within this study we show that for punctuate
paramagnetic structures the positioning of the perturber
relative to the imaging sampling grid has a notable
impact on the signal decrease of the acquired voxel.
This effect can be employed in order to boost the
contrast of labelled cells if the underlying 3D GRE
dataset is zeropadded and a minimum intensity projection
between the sub-voxel sampling points is calculated.
Simulations and in-vitro cell phantom experiments are
used to confirm our theory. The results show a
remarkable gain in negative contrast for iron-oxide
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