Abstract #3137
On the Lorentzian versus Gaussian Character of Time Domain Spin Echo Signals Sampled via Gradient Echoes: Implications for Iron Deposition Analyses
Robert V. Mulkern 1 , Mukund Balasubramanian 1 , and Dimitrios Mitsouras 2
1
Department of Radiology, Boston Children's
Hospital, Boston, Massachusetts, United States,
2
Department
of Radiology, Brigham and Women's Hospital, Boston,
Massachusetts, United States
Previous MRI studies of brain iron deposition have
estimated R2 and R2* (or R2') simultaneously from
multiple gradient echo sampling of either a single spin
echo or a free induction decay and the left side of a
spin echo. These studies have, explicitly or implicitly,
assumed Lorentzian frequency distributions for the water
resonance. Here, we demonstrate that Gaussian frequency
distributions, which have a markedly different time
domain response, provide a better fit to signals from
brain tissue, leading to a more accurate
characterization of both the reversible and the
irreversible transverse relaxation processes in these
tissues.
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