Interpretation of conventional APT contrast in tumor and ischemic tissue

APT provides a potential method for detecting changes in mobile proteins/peptides or pH, and has been applied to several pathologies including tumor and stroke. However, the in vivo contrast seen is complex and not fully understood. Here, we interpret the conventional APT contrast in tumor and postmortem tissues via experiments and simulations. We found that conventional APT contrast from asymmetry analyses of both tumor and ischemia CEST data at lower fields (e.g. 4.7T) is derived mostly from amine especially at high irradiation power, whereas contrast from tumors at high field (e.g. 9.4T) comes mostly from the MT asymmetry and NOEs.

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