pH-sensitive MR imaging without dependence on labile proton concentration
Tao Jin 1 and Seong-Gi Kim 1,2
Department of Radiology, University of
Pittsburgh, Pittsburgh, Pennsylvania, United States,
for Neuroscience Imaging Research, Department of
Biological Sciences, SKKU, Suwon, Korea
The pH is an important index of celluar function.
Chemical exchange-sensitive MRI techniques that provide
pH-weighted imaging have already been applied to stroke
and evaluation of cell viability in celluar therapies.
However, chemical exchange signals are dependent on both
labile proton concentration and exchange rate (i.e.,
pH), so in the many preclinical and clinical
applications where labile proton concentrations
significantly change, these pH-weighted signals are
considerably contaminated. Correct interpretation of
signal changes therefore requires an imaging method
highly-sensitive to generation of pure pH contrast, with
no dependence on labile proton concentration, as is
proposed in this study.
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