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Abstract #3317

pH-sensitive MR imaging without dependence on labile proton concentration

Tao Jin 1 and Seong-Gi Kim 1,2

1 Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States, 2 Center for Neuroscience Imaging Research, Department of Biological Sciences, SKKU, Suwon, Korea

The pH is an important index of celluar function. Chemical exchange-sensitive MRI techniques that provide pH-weighted imaging have already been applied to stroke and evaluation of cell viability in celluar therapies. However, chemical exchange signals are dependent on both labile proton concentration and exchange rate (i.e., pH), so in the many preclinical and clinical applications where labile proton concentrations significantly change, these pH-weighted signals are considerably contaminated. Correct interpretation of signal changes therefore requires an imaging method highly-sensitive to generation of pure pH contrast, with no dependence on labile proton concentration, as is proposed in this study.

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