Abstract #3650
Accuracy of MR elastography (MRE)-determined liver shear stiffness for the diagnosis of non-alcoholic steatohepatitis (NASH) and advanced fibrosis in adults with known or suspected non-alcoholic fatty liver disease (NAFLD)
Nikolaus M Szeverenyi 1 , Claude Sirlin 1 , William M Haufe 1 , Michael S Middleton 1 , Yu Shi 2 , Kevin Glaser 2 , Richard Ehman 2 , and Rohit Loomba 1
1
Univ. of California, San Diego, San Diego,
CA, United States,
2
Mayo
Clinic, MN, United States
This prospective study was performed to assess the
accuracy of MR elastography (MRE)-derived shear
stiffness values as predictors for non-alcoholic
steatohepatitis (NASH) and advanced fibrosis in adults
with known or suspected non-alcoholic fatty liver
disease (NAFLD), using contemporaneous liver biopsy as
reference. We found that MRE acquired using relatively
low-frequency mechanical waves and a 3D inversion
algorithm provides high accuracy in the diagnosis of
NASH and advanced fibrosis in patients with NAFLD.
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