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Abstract #3679

Non-Contrast Assessment Microvascular Blood Flow Fraction to Evaluate Treatment Efficiency of MR guided High-Intensity Focused Ultrasound (MR-HIFU) Surgery of Uterine Fibroids

Feifei Qu 1 , Amol Pednekar 2 , Pei Hor 1,3 , Claudio Arena 4 , Janie Swaab 4 , Debra Dees 4 , Brenda Lambert 4 , and Raja Muthupillai 4

1 University of Houston, Houston, TX, United States, 2 Philips Healthcare, Houston, TX, United States, 3 Texas Center for Superconductivity, Houston, TX, United States, 4 Diagnostic and Interventional Radiology, St. Luke's Medical Center, Houston, TX, United States

In this study, we sought to evaluate non-contrast imaging alternatives that can yield information regarding MR-HIFU treatment efficiency. In specific, we evaluate the following MR metrics for evaluating MR-HIFU treatment efficiency: (a) T2 maps (surrogate for edema), (b) Blood-flow fraction (f) maps (surrogate for tissue perfusion weighted imaging (PWI) or low b-value diffusion acquisition), and (c) ADC maps estimated from Diffusion Weighted Imaging (high b-value DWI as a surrogate for restricted diffusion). PWI (low b value) is a non-contrast alternative to conventional NPV based estimation of MR-HIFU treatment efficiency. The blood-volume fraction map (f-maps) provide better delineation between treated and untreated regions than T2 map, or conventional ADC map, and is more insensitive to other confounding factors such as T2 changes after HIFU treatment

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