Abstract #3679
Non-Contrast Assessment Microvascular Blood Flow Fraction to Evaluate Treatment Efficiency of MR guided High-Intensity Focused Ultrasound (MR-HIFU) Surgery of Uterine Fibroids
Feifei Qu 1 , Amol Pednekar 2 , Pei Hor 1,3 , Claudio Arena 4 , Janie Swaab 4 , Debra Dees 4 , Brenda Lambert 4 , and Raja Muthupillai 4
1
University of Houston, Houston, TX, United
States,
2
Philips
Healthcare, Houston, TX, United States,
3
Texas
Center for Superconductivity, Houston, TX, United
States,
4
Diagnostic
and Interventional Radiology, St. Luke's Medical Center,
Houston, TX, United States
In this study, we sought to evaluate non-contrast
imaging alternatives that can yield information
regarding MR-HIFU treatment efficiency. In specific, we
evaluate the following MR metrics for evaluating MR-HIFU
treatment efficiency: (a) T2 maps (surrogate for edema),
(b) Blood-flow fraction (f) maps (surrogate for tissue
perfusion weighted imaging (PWI) or low b-value
diffusion acquisition), and (c) ADC maps estimated from
Diffusion Weighted Imaging (high b-value DWI as a
surrogate for restricted diffusion). PWI (low b value)
is a non-contrast alternative to conventional NPV based
estimation of MR-HIFU treatment efficiency. The
blood-volume fraction map (f-maps) provide better
delineation between treated and untreated regions than
T2 map, or conventional ADC map, and is more insensitive
to other confounding factors such as T2 changes after
HIFU treatment
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