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Abstract #3787

Associations of glutamate, membrane phospholipid and high energy metabolism a combined 1 H- and 31 P-MR spectroscopic imaging study

Alexander Gussew 1 , Stefan Smesny 2 , Reinhard Rzanny 1 , Patrick Hiepe 1 , and Jrgen R. Reichenbach 1

1 Medical Physics Group, Department of Diagnostic and Interventional Radiology I, Jena University Hospital, Jena, Thuringia, Germany, 2 Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Thuringia, Germany

This study combined 1 H- and 31 P-MR brain spectroscopy to assess the associations between the neurotransmitter glutamate, the membrane phospholipid precursors (PME) and breakdown products (PDE) and the energy turnover markers (PCr) in healthy subjects. Significant positive correlations were observed between glutamate and PDE (rho>0.3), indicating for the glutamatergic modulation of membrane phospholipid breakdown. Furthermore, PDE increased with decreasing PCr (rho < -0.25), indicating increased energy demand to compensate the increased membrane turnover.

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