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Abstract #3847

Impaired venous return due to right ventricular diastolic stiffness in Pulmonary Arterial Hypertension

J. Tim Marcus 1 , Marielle van de Veerdonk 2 , Frank Oosterveer 3 , Rudolf Verdaasdonk 1 , and Anton Vonk Noordegraaf 2

1 Physics & Medical Technology, VU University Medical Center, Amsterdam, Netherlands, 2 Pulmonology, VU University Medical Center, Netherlands, 3 VU University Medical Center, Netherlands

The aim was to explore the association between Vena Cava (VC) backflow and right ventricular (RV) diastolic stiffness in pulmonary arterial hypertension (PAH). In 35 PAH patients, VC flow was measured by MRI velocity quantification, and right heart pressures by catheterization. The VC backflow fraction was related to the right atrium maximal pressure (p<0.00001, r2=0.53), and to RV diastolic stiffness (p<0.00001, r2=0.53). This explains the impact of RV diastolic dysfunction on right atrial pressure and subsequently on the venous return in PAH.

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