Imaging microstructure: Application of oscillating gradient diffusion sequences on a 3T clinical MRI scanner

Estimation of brain micro-structure parameters can be used to improve understanding of neuro-degeneration due to ageing or dementia. Recent studies show these estimations are possible using pulsed gradient spin echo sequences but are more accurately estimated using trapezoidal oscillating gradient spin echo (tOGSE) sequences. Here, we implement tOGSEs on a 3T MRI scanner and test its feasibility by imaging: (1)microcapillaries (2)an asparagus stem and (3)the corpus callosum of two healthy volunteers. Their fiber diameters were estimated using only 5 measurements with the three-stage fitting model procedure. Our results suggest good agreement with the ground truth and histology for our phantoms.

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